Learn more. The term prognosis refers to making an educated guess about the expected outcome of any kind of health treatment, including mental health, in essence making a prediction of the process an individual may have to go through in order to heal, and the extent of healing expected to take place. Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF-alpha therapy. We demonstrated that lymph node metastasis, residual tumor, adjuvant chemotherapy, and serum CA19-9 level were also independent prognostic indicators in this study. Ann Intern Med. We first compared the AUC values of the ROC curves for platelet-related indicators (platelet count, MPV, PDW) and CA19-9 in relation to OS. poor bet. Google Scholar. PDGF also inhibited the cell-killing effects of natural killer cells [18].   Prognostic Factors in Lymphoma . Goonetilleke KS, Siriwardena AK. These observations suggest the possible usefulness of platelet indices as a prognostic indicator in cancer patients, including patients with PC. 2011;17(1):47–58. Oncotarget. The AUC was highest for MPV among the four indicators (Fig. Wang X, Cui MM, Xu Y, Liu L, Niu Y, Liu T, Liu ZP, Wang RT, Yu KJ. The seventh edition of the General Rules for the Study of Pancreatic Cancer by the Japan Pancreas Society was used to evaluate lymphatic invasion, venous invasion, and perineural invasion [15]. California Privacy Statement, poor prognostic sign definition in English dictionary, poor prognostic sign meaning, synonyms, see also 'poor box',poor law',poor mouth',poor rate'. Platelets in tumor progression: a host factor that offers multiple potential targets in the treatment of cancer. The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Predicting the prognosis of cancer patients is important for determining treatment strategies and enabling informed consent to be obtained from patients and their families for treatment of various cancer types. Inflammation is closely related to cancer development and progression [28]. A dirt-poor person or place is extremely poor. Google Scholar. A Manchester score is an indicator of prognosis for small-cell lung cancer. See Synonyms at predict. PubMed Google Scholar. 1981;95(5):636–41. Angiogenesis. J Cell Physiol. PubMed  Furthermore, excessive pro-inflammatory cytokines interfere with megakaryopoiesis, leading to an increased production of small-sized platelets from the bone marrow [26]. outside shot. We then determined if the patients’ prognosis could be predicted in more detail using MPV combined with CA19-9, as the most common oncological serum marker in PC patients. Pietrzyk L, Plewa Z, Denisow-Pietrzyk M, Zebrowski R, Torres K. Diagnostic power of blood parameters as screening markers in gastric cancer patients. 2014;157(2):382–94. Gunsilius E, Petzer A, Stockhammer G, Nussbaumer W, Schumacher P, Clausen J, Gastl G. Thrombocytes are the major source for soluble vascular endothelial growth factor in peripheral blood. Mean platelet volume (MPV) is a commonly used index of platelet size that has recently attracted attention as a novel prognostic indicator. TY and HS participated in the design of the study, interpretation of data, analysis, and drafting the article. 8th ed. Long Y, Wang T, Gao Q, Zhou C. Prognostic significance of pretreatment elevated platelet count in patients with colorectal cancer: a meta-analysis. Survival curves according to MPV. Weissmueller S, Manchado E, Saborowski M, Morris JPt, Wagenblast E, Davis CA, Moon SH, Pfister NT, Tschaharganeh DF, Kitzing T, et al. We previously reported the NLR as a poor prognostic marker in bladder cancer, upper-urothelial carcinoma, adrenocortical carcinoma, penile … is no uniform definition of poor prognostic factors. First, its retrospective design was associated with some bias. 3b). 2. However, the current study did not provide data to directly support these hypotheses, and further investigations are required to clarify the detailed mechanisms responsible for the close relationship between decreased MPV and poor prognosis in PC. Platelets play a pivotal role in cancer metastasis and progression [3]. All rights reserved. Platelet activation and the spread of inflammation might thus explain why a decreased MPV was closely related to poor prognosis in patients with PC. Thirteen patients (14.3%) were treated with neoadjuvant chemotherapy (gemcitabine and S-1, n = 10; S-1, n = 2; gemcitabine and Nab-paclitaxel, n = 1) and 52 patients (57.1%) were treated with postoperative adjuvant chemotherapy (S-1, n = 39; gemcitabine, n = 13). However, information to guide physicians on the best choice of therapy in these patients is limited. A total of 91 PC patients who underwent pancreatectomy were included in this study. Prognosis definition: A prognosis is an estimate of the future of someone or something, especially about... | Meaning, pronunciation, translations and examples Platelets also produce cytokines such as thymidine phosphorylase/platelet-derived endothelial cell growth factor (PDGF) and transforming growth factor-β1 (TGF-β1). Gasparyan et al. Matsumoto T, Okabayashi T, Sui K, Morita S, Iwata J, Shimada Y. Preoperative neutrophili-to-lymphocyte ratio is useful for stratifying the prognosis of tumor markers-negative pancreatic cancer patients. Search poor prognosis and thousands of other words in English Cobuild dictionary from Reverso. Yagyu, T., Saito, H., Sakamoto, T. et al. Receiver operating characteristic curves for overall survival. Brierley JDGM, Wittekind C. TNM classification of malignant tumours. These factors are acknowledged to be of importance for the course of RA [2]. Find another word for prognosis. This study included 91 patients with pancreatic ductal adenocarcinoma who underwent pancreatoduodenectomy, distal pancreatomy, or total pancreatomy at our institution between January 2008 and December 2017. We thank H. Nikki March, PhD, and Susan Furness, PhD, from Edanz Group (www.edanzediting.com/ac) for editing drafts of this manuscript. 2014;83(1):97–101. Global cancer statistics, 2012. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Prognostic factors for all clear cell carcinomas of the vagina include stage at diagnosis, tumor size, and grade of the lesion, including architecture and nuclear grade, and appear to pertain equally to patients both DES-exposed and DES-unexposed. Google Scholar. Refaai MA, Phipps RP, Spinelli SL, Blumberg N. Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes. We demonstrated the prognostic superiority of the combined analysis of MPV and serum CA19-9 level compared with either MPV or serum CA19-9 level alone. Mol Clin Oncol. Furthermore, mutant p53-induced upregulation of PDGF receptor beta drives invasion and metastasis in PC [17]. Japan Pancreas Society. In common practice when someone is so sick that we are focusing on purely palliative ends, comfort care, it means that the patient’s prognosis is limited, bad, even grim. Because platelets play important roles as inflammatory regulators, their activation also enhances cancer-associated inflammation. The authors declare that they have no competing interests. 7th ed. http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12893-020-00976-5. Multivariate analysis identified MPV as an independent prognostic indicator for both OS and DSS. Among the tumor-related prognostic indicators, we focused on serum CA19-9, because serum CA19-9 levels can be easily obtained from preoperative blood examination. 2015;3(1):197–201. Decreased mean platelet volume (MPV) predicts poor prognosis in some cancers. b Disease-specific survival. The clinical usage of carbohydrate antigen 19-9 (CA19-9) as a marker in PC patients is recommended by the National Comprehensive Cancer Network guidelines. Am J Surg. b Disease-specific survival. Pancreatic cancer (PC) is one of the most aggressive tumors with a 5-year overall survival (OS) rate of less than 5% worldwide [10, 11]. Platelet-derived endothelial cell growth factor. ROC analysis showed that the AUC of the combined analysis of MPV and serum CA19-9 level was higher than that of either MPV or serum CA19-9 level alone for both OS (AUC = 0.815; P < 0.0001; Fig. Surg Oncol Clin N Am. CAS  This study was approved by Certified Review Board, Tottori University Hospital, and the requirement for informed consent was waived. The present study had some limitations. Hepatogastroenterology. By using this website, you agree to our Data obtained from routine blood examinations meets these criteria. Ritts RE, Pitt HA. Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Tottori, Japan, Takuki Yagyu, Teruhisa Sakamoto, Ei Uchinaka, Masaki Morimoto, Takehiko Hanaki, Joji Watanabe, Tomoyuki Matsunaga, Manabu Yamamoto, Naruo Tokuyasu, Soichiro Honjo & Yoshiyuki Fujiwara, Department of Surgery, Japanese Red Cross Tottori Hospital, 117 Shotoku-cho, Tottori, 680-8517, Japan, You can also search for this author in Int J Gynecol Cancer. These are tumor-related indicators, whereas MPV is a patient-related indicator. Platelets enhance the penetration of cancer cells through the blood vessel endothelial cell barrier, and prevent their clearance from the circulatory system by the immune cells [16]. poor prognosis definition in the English Cobuild dictionary for learners, poor prognosis meaning explained, see also 'poor relation',dirt poor',poo',poorly', English vocabulary Grivennikov SI, Greten FR, Karin M. 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